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The BIOFIRE System and Your Immune System

The BIOFIRE System provides syndromic infectious disease testing, empowering healthcare professionals to choose the right test the first time. Patients benefit from quicker diagnosis and a more specific treatment. Clinicians benefit from improved antibiotic stewardship. Labs save money while increasing efficiency.

The BioFire FilmArray Pneumonia plus panel (PN panel) examines native sputum, endotracheal aspirate, and bronchoalveolar specimens (including mini-BAL) for 33 pathogens with clinical relevance and antimicrobial resistance genes with semiquantitative results that take less than an hour.

Respiratory

The burning of biomass, like wood, plants and other organic materials produces gaseous pollution and fine particles that adversely affect the respiratory system. Climate change can exacerbate the negative impacts of forest fires on the health of humans.

In the United States wildfire smoke is associated with hospitalizations for respiratory diseases like asthma, COPD, and lung cancer. This kind of pollution can also increase the risk of developing cardiovascular diseases and is a major contributor to the burden on disease among the most vulnerable populations.

The wildfires have caused unhealthy levels of air pollutants in many communities during the COVID-19 epidemic. However the response of public health officials to this environmental problem is sporadic and mainly focused on educating people about symptom management. This knowledge gap is alarming, due to the fact that smoking cigarettes and other sources of air pollution can cause health problems.

Researchers are currently assessing the best way to safeguard public's health during future events of this nature. NIH is funding research on this important public health issue through the BLUE CORAL study as well as its successor, unwro.org FIRE CORAL.

For the first time an prospective cohort study will examine long-term effects resulting from exposure to smoke from wildfires and other sources. FIRE CORAL is looking for adult participants hospitalized for COVID-19's index episode who speak English or Spanish and are not pregnant. The Fire Coral protocol includes a battery in-person assessments that objectively measure the pulmonary function testing, lung imaging and functional assessment.

Smoke and other particles can trigger or worsen respiratory conditions such as emphysema, COPD, and pneumonia. A variety of steps can be taken to prevent or lessen the negative health effects of exposure to smoke, which includes avoiding outdoor activities when possible and wearing the EPA's "N95" mask that is designed to capture fine particles.

Smoking can cause irritation to the throat, eyes and nose. To reduce the symptoms, the lungs should be flushed by drinking plenty of water and taking medications that decrease inflammation, such as corticosteroids.

Bloodstream

Bloodstream is the first line of defense against germs that invade your system. Dendritic cells, which are special cells, are like your fire department's call centre; they take antigens (molecules that trigger an immune response) from invading germs and release proteins that signal other white blood cells to to fight them. Circulating white blood cells, differentials, and band cells were increased after firefighters' firefighting shifts, and compared to levels after strenuous physical exertion without firefighting.

Skin

As the wildfires in California produced smoke and dust into the air this past winter and fall dermatologists were concerned about how that might affect the skin of those exposed to it. Maria Wei, a graduate student at University of California, Irvine is studying how severe wildfire pollution affects the skin. Her research was published on April 22, 2012 in Scientific Reports.

The research of Wei shows that the temperature of the skin varies based on the length of time that the body is exposed to flames. It could take up to two hours for the skin of a person to reach its "flash point"--the place where it begins to burn and turn into ash. It's important not to stay near a Bio Ethanal Fire pit or campfire and wear protective clothing when going outside during a hot or humid day.

While it is important to take precautions against wildfire-related pollution, there's no way to stop forest fires from occurring. Wei is predicting that the number of people suffering the consequences of wildfires will increase as climate change causes more and more forests to be burned. This means that more people will need to wear hats and long sleeves as well as thick moisturizers.

Wildfire air pollution can also exacerbate atopic skin dermatitis, which is a condition that causes itchy skin in many people. It is believed that this is because smoke particles can block pores, which makes the condition worse.

Another issue is the fact that atopic dermatitis tends to make people more sensitive to UV light, which can also be aggravated by smoke from wildfires. This can result in people seeking out tanning salons and apply a tan with less protection.

A treatment using ice and fire can help reduce atopic skin conditions however it is not recommended for anyone with an open wound or rash. Patients with active acne should avoid it, and if you're breastfeeding or pregnant, it's recommended to avoid this procedure altogether. The IS Clinical Fire & Ice Facial, at Novuskin Las Vegas' premier membership MedSpa is a result-driven, intensive facial that bridges between an easy facelift and a peel, but without the need for downtime. It is designed to resurface skin, improve rosacea and reduce fine lines and acne scarring and also stimulate cellular regeneration. It's an incredible treatment that will give you a radiant glow.

Infections

The human body is comprised of a complex set of organs and tissues which work together to protect us against infection. Infections can be caused by microorganisms such as bacteria, viruses and parasites that invade healthy cells and cause them to multiply uncontrollably. Your immune system may react by displaying signs of illness. These symptoms can include a runny nose to a stomach that is upset as well as swelling of lymph glands or an scratch. The symptoms you experience can be affected by the nature of the infection, its location, and even your temperature.

Infections spread in many ways however the most common are transmitted from person to person by droppings that hang in the air after coughing or sneezing. This is how bacterial infections like strep, tuberculosis and meningococcal illnesses and viral infections like the common cold and influenza, are spread. Certain bacterial infections, such as skin infections and sexually transmitted infections (STIs) like gonorrhea or chlamydia are transmitted by contact with infected tissue or mucous membranes, or through indirect contact with surfaces that are contaminated. Certain bacterial infections are transmitted by insects, such as ticks, fleas or mosquitoes.

Viruses, parasites and other microorganisms are tiny enough to be able to get into the bloodstream and cause infection to your cells. This can lead to serious diseases like the common cold or AIDS. Fungi can cause skin conditions such as ringworm and athlete's foot, while others infect the lungs and nervous system.

The BioFire PN Panel uses our revolutionary FilmArray technology to analyze an extensive list of pathogens involved in upper respiratory infections in sputum or samples of bronchoalveolar fluid. The kit comes with a reagent kit that contains all the chemistry necessary to perform reverse transcription, nested multiplex PCR and detection in a single machine. This is a simple solution that helps clinicians identify and treat patients who have various respiratory symptoms. This test has been issued an Emergency Use Authorization. It's available in bioMerieux CLIA medium and high complexity labs.