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Mesothelioma is Caused by Exposure to Asbestos

Mesothelioma can be triggered by asbestos exposure. Asbestos fibers can cause irritation to the organ's lining and lead to DNA damage that creates mesothelioma tumors.

Workers who work with asbestos take these tiny fibers on their clothing hair, tools and even their hair and put their loved ones at risk of exposure through secondhand sources. The chemicals found in the clothing of their spouse can also cause mesothelioma.

Asbestos

Asbestos is one of the minerals that are naturally formed as bundles of tiny fibers. When asbestos is broken or disturbed, these fibers can float into the air and be inhaled. When this happens, the asbestos may enter the airways with the smallest size and cause irritation to the lung's lining (the pleura). The irritation can cause cells to develop abnormally and eventually turn into mesothelioma tumors. Mesothelioma may be affecting other parts of the body that have the same lining. These include the peritoneum (the abdominal lining) and the heart or the testicles.

Asbestos exposure has been linked to mesothelioma by medical records and other studies. However, scientists aren't able to comprehend why certain individuals are more prone to developing mesothelioma than other people. They have found that the type of asbestos used and how does asbestos cause mesothelioma much exposure someone had affects their risk of developing this cancer.

The most frequent asbestos types associated with mesothelioma are chrysotile and ambole asbestos. They were used in household and industrial products, such as drywall pipes, insulation cement, talcum powder and cement. The greatest risk is for those exposed to these substances at work. They typically worked in industries like electrical work, construction and shipbuilding, as well as military service. Due to their past, men are more likely to develop mesothelioma than women.

When asbestos fibers are introduced into the body, they adhere to tissue that lines organs, such as the chest wall, lungs the intestines, abdomen and chest wall. Mesothelium is a thick and tough material that can resist damage. Asbestos fibers may get trapped in the mesothelium and remain there for years or decades. This can cause chronic irritation that could eventually result in a mesothelioma tumour.

Mesothelioma is a type of cancer that is caused by DNA mutations which cause a cell to divide unchecked. This leads to the formation of a cancerous tumor. Researchers have identified a variety of factors that can increase the risk of a person developing mesothelioma, such as a family history of the disease as well as prior asbestos exposure. Mesothelioma is a rare condition that can take years to develop. People who have an history of exposure should see their doctor for any symptoms or signs that concern them.

Erionite

Erionite is found in close proximity to asbestos. Similar to asbestos, it is known to cause mesothelioma particularly mesothelioma pleural. It is also associated with the peritoneal cancer. Erionite is a type of natural mineral that is part of the group of minerals known as zeolites. Electron microscopy has been used to study morphological changes on erionite. These studies show that fibers of erionite exhibit a diverse structure. They can appear as ribbon-like bundles that are regular in shape or rod-like structures, based on the nanostructural properties of the erionite.

In a long-term study of the residents living in villages that were exposed to erionite, Baris & Grandjean (2006) found that the death rate for mesothelioma to be significantly higher in these communities compared to a control village which was not exposed to erionite. 119 mesothelioma-related deaths and seven mesothelioma-related peritoneal mesothelioma not caused by asbestos cases were documented in the villages exposed to the mineral over a time period of 23 years. The researchers concluded that erionite is more mesotheliomagenic than any of the amphiboles (antophyllite, actinolite crocidolite, and amosite) currently classified as asbestos.

It is possible that the structural resemblance between asbestos and erionite is the reason for mesothelioma. In a study of rats, the erionite-induced mesothelioma had a similar cellular response as in the case of the rats exposed to asbestos. Mesothelioma that was caused by erionite had an increased Bax expression, and a decreased Fas ligand.

The Department of Transportation in North Dakota has been working with local businesses and counties to restrict the use of gravel containing the mineral erionite. The department continues to monitor research into erionite and keep citizens of the state informed of the issue. Erionite is found in a variety of areas of the United States including Oregon, Idaho and Arizona. Researchers will be able examine samples from these areas with mesotheliomagenic Erionite from Turkey when they are able to determine Erionite. This data could help determine the incidence of mesothelioma in the U.S. and lead to more effective screening and prevention strategies for those exposed to this substance. It can take 30 to 60 years for mesothelioma to develop, so this work is crucial.

Silica

Silica or quartz is a common industrial material that is found in the earth crust. It is utilized in a variety of industries including mining, construction, and agriculture. Inhaling silica may cause lung diseases like silicosis and lung cancer, depending on the nature of the work. Silica exposure can also increase the risk of developing mesothelioma. It is a highly aggressive and potentially fatal form of lung cancer that could develop in the mesothelium.

Both the International Agency for Research on Cancer and the Occupational Safety & Health Administration classify inhaled crystalline silicon as a substance that can cause cancer in humans. This is based on solid evidence that exposure to inhaled silica can cause lung cancer. However, the IARC does asbestos cause mesothelioma (123.138.18.15) not yet acknowledge the role played by silica in the development of other forms of cancer, such as mesothelioma and bladder cancer.

Inhalation of asbestos and mineral fibers is related to mesothelioma. Mesothelioma is caused by chronic irritation and aggregation in the mesothelium. Inhaling other mineral fibers, such as silica and mineral wool compounds this effect by causing further irritation to the mesothelium. The majority of mesothelioma cases are diagnosed in people over 45 because it takes years for the disease to progress. Men are more likely to be diagnosed with the disease than women due to the fact that they were exposed to silica and asbestos at work.

Asbestos, silica and other substances are recognized as carcinogens to the lungs. The IARC and the U.S. Environmental Protection Agency both recognize mesothelioma and various cancers as a result of these exposures. The mechanisms behind how carcinogens play in the development of organ sites in other organs is less understood. The physics and chemistry of asbestos and silica that are inhaled determine their removal from the lungs and how much asbestos can cause mesothelioma they are transported to other organs, such as the bladder.

The authors of a new population-based study characterized the association between asbestos and silica dust in the workplace exposure and bladder cancer risk using data from the National Enhanced Cancer Surveillance System in eight Canadian provinces. Exposures to a wide range of asbestos dusts and silica were identified in the cohort with the highest level and frequency of exposure observed in the mining, construction, masonry and quarrying, and manufacturing industries.

Other Minerals

Minerals are solid substances that form naturally on the Earth. They have distinct chemical and physical properties, and most minerals have an ordinary crystal structure. Examples include asbestos and barium. Both are soft metallic elements that are used in x-ray technology, fireworks and rubber manufacturing. People exposed to these minerals in the workplace could be exposed to asbestos fibers in clothing and personal items. These are then taken home and [empty] family members are able to take them in or swallow them.

Asbestos may cause mesothelioma to develop in 70 to 80 percent of all cases diagnosed. However, a small percentage of cases have been linked to non-asbestiform minerals. These minerals include erionite and other forms silica as well as non-asbestiform grunerite utilized in mining operations.

The chest is where the mesothelioma symptoms usually begin. They can manifest as swelling, pain and difficulty breathing. The most common site of development is in the pleura which protects your diaphragm and the lung tissue. The disease can also develop in the peritoneum, which covers your stomach and the intestinal tract. In some cases, mesothelioma can be spread to other parts of your body.

In generally, it takes 20 years or more for mesothelioma pleural to develop after asbestos exposure. Many people suffering from asbestos-related illnesses do not seek medical attention until they have serious symptoms. For instance the accumulation of fluid or persistent chest pain.

The type of treatment you receive for mesothelioma will depend on the extent of your illness and the extent to which it has spread. Your doctor may prescribe treatments to help manage symptoms and prolong your life. You might be prescribed powerful painkillers or have fluid removed from your lungs to relieve your discomfort.

In addition to treatment for your symptoms, your doctor will typically prescribe medications to fight cancer cells or slow their growth. Chemotherapy is among the most common treatments for pleural melanoma and is a treatment that can be used by itself or in conjunction with other therapies. Other treatments include radiation and surgery. Surgery could involve the removal of a lung or a part of the diaphragm or combining it with radiation and chemotherapy.