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Multiple Myeloma and Aplastic Anemia

Aplastic anemia injury anemia can affect the bone marrow and blood (the sponge-like tissue inside bones which produces blood cells). The treatment is based on immunosuppressants (drugs that alter or suppress your immune system) and the transplantation of blood stem cells using healthy donor cells.

Bone marrow transplants treat severe aplastic anemia (SAA) and extremely severe aplastic anemia (vSAA). It is best to do it when you have a matching sibling donor.

Causes

The bone Marrow (mal- -foh- The sponge-like tissue (-dre) within bones is responsible for the production of blood cells. These include red blood cells, white blood cells and platelets (PLA-tee-lets) which fight infection and help the body clot to stop bleeding. If you suffer from aplastic Anemia in which the bone marrow isn't able to make enough new blood cells.

Aplastic anemia railroad cancer settlement anemia can be caused by a variety of factors. Aplastic anemia can be caused by certain infections such as Epstein-Barr or hepatitis (the virus which causes mononucleosis). It could also be caused by a medicine or treatment like radiation therapy or chemotherapy to treat cancer or other conditions. Sometimes, it's because of a genetic condition like Fanconi anemia or Shwachman Diamond syndrome.

Some people with aplastic ahememia are cured with bone marrow transplants. The procedure is risky and may not be a viable option for all. People who can't get an organ transplant using bone marrow, or whose condition doesn't respond to the transplant, can be treated with medicines that suppress the immune system. These medications include antithymocyteglobulin (ATG) and Cyclosporine. Eltrombopag also known as Promacta is a second drug that helps some people with severe anemia.

Anemia caused by multiple myeloma usually improves with the continuation of the treatment for cancer. Your doctor myeloma aplastic anemia may suggest supplements to your vitamin intake or prescribe medications to increase the production of red blood cells such as epoetin alfa (Procrit or Epogen) and darbepoetin alfa (Aranesp). They can enhance your quality of life during multiple myeloma treatment.

Signs and symptoms

Aplastic anemia is caused by injury to your blood stem cells. These cells are immature blood cells that develop into red blood cells white blood cells and platelets. Your bone marrow cannot produce enough of these cells if you have anemia with Aplastic anemia railroad injury. Other blood cells could also be damaged. This condition is sometimes called acquired aplastic anemia. However, there are congenital or acquired bone marrow dysfunction syndromes that can manifest as anemia with aplastic components.

The severity of your anemia and the root cause will determine which symptoms you are experiencing. The most commonly reported symptoms are fatigue and weakness. They may struggle to fight off infections and get tired more often. Some people have headache dizziness, headaches, or a rapid heartbeat. Other symptoms include a feeling of pins and needles (numbness) in the legs and arms, or bone pain.

A blood test can check for aplastic anemia. Your doctor will take a sample of your blood and then look at it under microscope. Your doctor could also suggest an aspiration of bone marrow and biopsy. The doctor will extract tiny amounts of fluid from your bone using a needle. Your doctor will examine the marrow using an optical microscope to determine if it has any abnormal cells.

If your aplastic anemia isn't extreme, treatment includes medications and blood transfusions. You'll take medicines that suppress your immune system, such as anti-thymocyte globulin (ATG) and Cyclosporine. Transfusions of blood can help regain your strength and fight off infections.

Diagnosis

Aplastic anemia is the result of damage to the blood-forming cells in the bone marrow. This causes anemia (low levels of red blood cells, white blood cells and platelets). This can lead to fatigue, a tendency to fatigue, and an increased risk of infection. They also are at an increased risk of developing cancers, such as multiple myeloma, leukemia and myelodysplastic Syndrome.

A doctor can diagnose myeloma aplastic anemia through the blood test, also known as a complete blood count (CBC). The test determines the amount of several types of cells in the body, including platelets and white blood cells. It also looks for abnormal levels of clotting factor and protein. If a patient has a low blood-cell count, the doctor should look for other causes.

Treatment for myeloma aplastic may include a bone marrow transplant, radiation therapy or medicines that suppress the immune system (immunosuppressants). These medicines, like cyclosporine (Gengraf, Neoral) and anti-thymocyteglobulin, assist in keeping your immune system from attacking healthy tissues in the bone marrow as well as elsewhere in the body. You can also use erythropoietin medicines like Promacta (eltrombopag), which increases the number of red cells within the body.

Sometimes, doctors are unable to determine the cause of myeloma aplastic. In this case, the doctor will try to rule other conditions out like hepatitis and hemoglobinuria in the nighttime that is paroxysmal.

Treatment

In certain cases, aplastic anemia is treatable with blood transfusions that increase the number of healthy red and platelet cells. Your doctor may also decide to remove the spleen, to prevent it from removing worn-out cells which can cause anemia.

You may require medication that aids in helping your bone marrow create more blood cells. Examples include erythropoietin and the granulocyte colony stimulating factor. These are copies of substances that your body naturally produces. You may also require medicines to prevent or treat infections that may occur when your blood cells are low. Your doctor might prescribe antibiotics or other medications that destroy bacteria.

Your doctor might attempt to control the autoimmune response that is causing damage to your bone marrow through the use of medicines known as immunosuppressive agents. The standard therapy is antithymocyte globulin and cyclosporine or in certain situations it is combined with eltrombopag (Promacta).

Acute myeloidleukemia and other rare blood cancers can sometimes be identified by a bone-marrow biopsy. These types of leukemias can be typically associated with hypercellular bone marrow and peripheral blood lymphocytopenias.