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Railroad Aplastic Anemia

A bone marrow transplant is the only treatment for severe anemia that is aplastic. It is important to find an uninjured donor with a blood group that is compatible, usually siblings. Certain medications that inhibit the immune system, such as anti-thymocyteglobulin and the cyclosporine drug, can aid.

Railroad Black Lung Disease workers are at a higher risk of developing anemia due to of exposure to chemicals such as the benzene that is used in locomotive machinists' solvents and car department degreasers. The condition can be fatal if it is not treated promptly.

Exposures to Work

Many of the chemicals and other materials Railroad Non Hodgkins Lymphoma workers use to perform their jobs could be harmful to their health over long durations. These chemicals can be swallowed, inhaled, or taken in through the skin. Certain chemicals, like benzene, may cause severe and debilitating illnesses such as leukemia, or anemia aplastic.

Railroad Copd workers are frequently exposed to benzene by diesel exhaust. According to the Agency for Toxic Substances & Disease Registry Railroad Rad conductors, engineers and yard workers are at an increased risk of developing aplastic encephalopathy because of the exposure. The chemical is also present in organic solvents such as paint thinners, degreasers, and Lubricants. In addition, many insecticides, herbicides and paint removers contain benzene.

Aplastic anemia happens when the bone marrow ceases to produce new blood cells. Bone Marrow is a sponge-like structure inside the bones that makes stem cells which develop into red blood cells white blood cells, and platelets (PLATE-lets). Red blood cells transport oxygen to the tissues of the body. White blood cells fight infections, and platelets help stop bleeding when small cuts or breaks occur in the blood vessels.

Certain factors can increase the likelihood of developing aplastic anemia including prior radiation or chemotherapy treatment, as well as certain autoimmune disorders such as Rheumatoid Arthritis. Certain people are more vulnerable to the condition due to their genetics.

Symptoms

Red blood cells carry oxygen throughout the entire body. The absence of blood cells can result in anemia. This can lead to fatigue (tiredness) chest pains, weakness, headaches and fatigue. The anemia could be caused by a low count of hemoglobin, an iron-rich protein that aids in the transport of oxygen in the blood. A lack of white blood cells can make you more prone to infections. Also, a shortage in platelets could cause bleeding from minor cuts or injuries.

The bone marrow is the place where blood stem cells are created. These cells give birth to red and white blood cells, as well as platelets. Aplastic anemia is caused by damage to the blood stem cells that reside in the bone marrow. This can be caused either by cancer treatments such as chemotherapy or radiation, or conditions that cause autoimmune disease, like eosinophilic or lupus faciitis or paroxysmal hemoglobinuria at night.

The signs of aplastic anemia can be difficult to identify since they can resemble other health problems and could not be apparent for a long time. A doctor can diagnose aplastic anemia using blood tests as well as a bone marrow biopsy or aspiration. A bone marrow transplant is a possibility to be the cure for the disease.

Diagnosis

Aplastic anemia is caused by damage to the stem cells in your bone-marrow. When these stem cells become damaged, your body isn't able to produce enough healthy blood. The most common cause of this is due to an autoimmune disorder, in which your immune system attacks and destroys your own stem cells. Other causes include exposure to harmful chemicals or medications, such as chemotherapy drugs. Certain genetic diseases, such as paroxysmal nocturnal hemoglobinuria and Fanconi's Anemia, could cause this condition.

Your doctor will request blood tests if you suffer from anaplastic ahememia in order to determine the severity of the condition and its root cause. Your doctor will look for low platelet count as well as a low red blood cell count. He or she will also check your blood for vitamin B12 and folate, both of which are essential nutrients needed for healthy red blood cells.

Your doctor may prescribe growth factors or colony-stimulating agents, like sargramostim (Leukine) or filgrastim (Neupogen) and pegfilgrastim (Neulasta). These drugs stimulate your bone marrow, which produces more blood cells. These drugs are often combined with immune-suppressing medications. Your doctor will test your iron levels since excessive iron can cause aplastic aneurysm. If you are suffering from anemia as a result of these signs, then your doctor will recommend blood transfusions containing plates, red blood cells as well as folic or vitamin B12. If your anemia is severe your doctor may suggest that you undergo a bone-marrow transfusion.

Treatment

Aplastic anemia happens when the blood stem cells within the bone marrow (the sponge-like tissues inside your bones) are damaged. The stem cells in these tissues give rise to white blood cells and platelets. The damage to blood stem cells can be the result of a number of diseases and conditions. Certain medications, autoimmune conditions like lupus, eosinophilic faciitis and infections like HIV, hepatitis, or Epstein-Barr and exposure to chemicals or radioactivity are all possible causes. Aplastic anemia can be genetic in some cases.

It is vital to get a diagnosis early because the symptoms of aplastic anemia are similar to those of other conditions. If left untreated, severe anemia may lead to severe bleeding or infections.

The treatment options for Railroad Rad aplastic anemia differ however the most effective treatment is an organ transplantation. In this procedure, healthy bone marrow cells will replace your damaged marrow and return your blood cell count back to normal. While this treatment is not available, doctors treat the symptoms of aplasticanemia by using medications that reduce the immune system and increase the production of blood stem cells. Immunosuppressants, such as azathioprine, methotrexate and cyclosporine are employed. Bone marrow stimulants such as sargramostim (Leukine(r)) or filgrastim (Neupogen(r)) or epoetin alfa (Epogen(r)) may be used. These treatments can help alleviate the symptoms of aplastic angiopathy and stop the progression into myelodysplastic disease or Railroad Aplastic Anemia acute leukemia.