Ten Railroad Acute Myeloid Leukemias That Really Change Your Life | Caridad | 23-07-02 14:32 |
Railroad Aplastic Anemia
The only method to treat severe aplastic anemia is to have an organ transplant. It is important to find an uninjured donor with a matching blood group typically a brother or sister. Certain drugs that reduce the immune system such as anti-thymocyteglobulin, cyclosporine can help. Aplastic anemia is a more common condition in railroad workers because of exposure to chemicals such as benzene, which is used in locomotive machinists ' solvents and degreasers used by car departments. If not treated quickly the condition can become fatal. Exposure to Work Over time, a lot of chemicals and products railroad workers use are hazardous to their health. These chemicals can be inhaled, swallowed or absorbed via the skin. Some of these substances like benzene, for instance, can trigger serious and debilitating diseases like leukemia and anemia aplastic. Diesel exhaust is a frequent source of benzene exposure for railroad workers. According to the Agency for Toxic Substances & Disease Registry railroad conductors, engineers, and yard workers have a higher risk of developing aplastic encephalopathy due to this exposure. Benzene is also found in organic solvents, including paint thinners, degreasers and lubricants. In addition many herbicides, insecticides and paint removers contain benzene. Aplastic anemia occurs when the bone marrow ceases to produce new blood cells. The bone Marrow is a sponge-like organ that forms stem cells which develop into red and white blood cells, as well as platelets. Red blood cells supply oxygen to the tissues of your body. White blood cells aid in fighting infection and Railroad platelets stick together to stop bleeding from tiny cuts or ruptures in blood vessels. Aplastic anemia can be caused by a variety of factors, including radiation or chemotherapy treatments as well as certain autoimmune diseases like rheumatoid joint. Certain people are more vulnerable to the condition because of their genetics. Signs and symptoms Red blood cells carry oxygen throughout the body. The absence of blood cells can lead to anemia. This can cause fatigue (tiredness), chest pains headaches, weakness, and fatigue. The anemia could also be due to an insufficient amount of hemoglobin. This is an iron-rich protein that helps carry oxygen through the blood. The presence of fewer white blood cells can make you more susceptible to infections. Also, a low number of platelets means that bleeding from small cuts or injuries may not stop quickly. The bone marrow produces blood stem cells that give birth to white and red blood cells, as well as to platelets. The damage to the blood stem cells that reside in the bone marrow leads to anemia caused by aplastic substances. It can be caused by cancer treatments like chemotherapy or radiation, conditions that cause autoimmune disease, like eosinophilic lupus faciitis, or paroxysmal nighttime hemoglobinuria. The signs of aplastic anemia can be difficult to detect since they can resemble other health problems and could not appear for a long period of. A physician can diagnose anemia due to blood tests and a bone-marrow biopsy or aspiration. A bone marrow transplant may be the cure for the disease. Diagnosis Aplastic anemia is caused by damage to stem cells in your bone-marrow. These stem cells typically produce red blood cells, white blood cells and platelets, but when they're damaged your body's cells don't produce enough healthy blood cells. This problem is typically caused by autoimmune disorders, in which your immune system attacks your stem cells and destroys them. Other causes include exposure to harmful chemicals and certain medications, such as chemotherapy drugs. The condition could also be caused by certain inherited illnesses like Fanconi's anemia and paroxysmal-nocturnal hemoglobinuria. Your doctor will order blood tests if your have an aplastic ahememia condition to determine the severity of the condition as well as its cause. Your doctor will look for the presence of platelets as well as red blood cells. He or she will also check your blood for vitamin B12 and folate, which are essential nutrients for healthy red blood cells. Your doctor may prescribe colony-stimulating growth factors or other drugs like sargramostim(Leukine),filgrastim(Neupogen) or pegfilgrastim(Neulasta). These medications stimulate your bone marrow to ensure that it will produce more blood cells. These medications are usually combined with immune suppressing medications. Your doctor will also assess your iron levels since too much can contribute to aplastic anemia. If you're suffering from anemia caused by these signs Your doctor will treat it with blood transfusions of platelets, red blood cells and, in some cases, folic acid or vitamin B12. If your anemia has become severe, your doctor may suggest that you undergo a bone marrow transplant. Treatment Aplastic anemia is a condition that occurs when blood stem cells in the bone marrow (the sponge-like tissues inside your bones) are damaged. These stem cells make red blood cells, as well as plates and railroad white blood cells. The damage to blood stem cells may be caused by a variety of illnesses and conditions. Certain medications, autoimmune disorders like lupus, eosinophilic faciitis and infections such as HIV, hepatitis, or Epstein-Barr and exposure to radioactivity or chemicals are all possible causes. Aplastic anemia can be genetic in some instances. The early diagnosis is essential because the symptoms of aplastic ahememia may be similar to those of other conditions. If left untreated, severe aplastic anemia can cause serious bleeding or infections. Treatment options for the condition are numerous however a bone-marrow transplant is the most efficient. In this procedure, healthy cells from bone Marrow replace damaged marrow to restore your blood count to normal. Doctors treat the symptoms of Aplasticanemia until the treatment becomes available. They employ medications that inhibit the immune system and boost the production of blood stem cells. These include immunosuppressants like azathioprine (Azulfidine(r)), methotrexate (Methotrexate(r)) and Cyclosporine (Gengraf(r)). Bone marrow stimulating agents such as Neupogen, filgrastim and sargramostim (r) or epoetin (r) can also be utilized. These treatments can help improve the symptoms of aplastic angiopathy and stop the progression into myelodysplastic disease or acute leukemia. |
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